| Rehaciendo Comunidades Con Esperanza INC | Other Services (except Public Administration) | $1,563,800 | $1,588,126 | 65 | N/A |  Research |
| Island Wide Logistics | Transportation and Warehousing | $1,545,000 | $1,559,720 | 383 | $29.8M | Research |
| Rsm Puerto Rico | Professional, Scientific, and Technical Services | $1,528,300 | $1,537,662 | 142 | $45.2M | Research |
| Asociacion Hospital Del Maestro Inc. | Health Care and Social Assistance | $1,525,000 | $1,545,842 | 2 | N/A | Research |
| Condado Duo La Concha Casino Spv LLC | Accommodation and Food Services | $1,506,500 | $1,472,933 | 217 | $67.9M | Research |
| Baristas Del Caribe, LLC | Accommodation and Food Services | $1,485,000 | $1,499,314 | 500 | $88.8M | Research |
| Super Asphalt Pavement Corp | Manufacturing | $1,456,900 | $1,472,319 | 346 | $343.2M | Research |
| Boys & Girls Clubs of Pr INC | Health Care and Social Assistance | $1,410,000 | $1,421,828 | 447 | N/A | Research |
| A Pereza LLC | Retail Trade | $1,391,300 | $1,404,015 | 500 | $124.8M | Research |
| Ferraiuoli LLC | Professional, Scientific, and Technical Services | $1,359,800 | $1,368,337 | 104 | $25.3M | Research |
| Hato Rey Pathology Associates Inc. | Health Care and Social Assistance | $1,354,900 | $1,367,094 | 223 | $51.7M | Research |
| Hato Rey Pathology Associates Inc. | Health Care and Social Assistance | $1,354,900 | $1,370,368 | 223 | $51.7M | Research |
| Boys & Girls Clubs of Pr INC | Health Care and Social Assistance | $1,319,800 | $1,336,261 | 285 | N/A | Research |
| Instituto Comercial De Puerto Rico INC | Educational Services | $1,258,200 | $1,266,763 | 181 | $21.7M | Research |
| Central Drug Dorado Corp | Wholesale Trade | $1,257,100 | $1,269,706 | 434 | $111.7M | Research |
| Best Option Healthcare Puerto Rico Inc. | Health Care and Social Assistance | $1,250,839 | $1,259,664 | 130 | $22.3M | Research |
| Liga Puertorriquena Contra El Cancer INC | Health Care and Social Assistance | $1,247,600 | $1,257,685 | 231 | N/A | Research |
| Condado Plaza Investments LLC | Accommodation and Food Services | $1,246,427 | $1,262,665 | 298 | $93.2M | Research |
| Rodriguez Vidal Corp | Retail Trade | $1,223,700 | $1,233,524 | 313 | $94.7M | Research |
| Rodriguez Vidal Corp | Retail Trade | $1,222,800 | $1,233,228 | 296 | $89.5M | Research |
| Airport Shoppes and Hotels Corp. | Accommodation and Food Services | $1,216,255 | $1,231,762 | 205 | $64.1M | Research |
| The Money House INC | Finance and Insurance | $1,204,753 | $1,219,478 | 105 | $53.9M | Research |
| Flexible & Integrated Technical Services, LLC | Administrative and Support and Waste Management | $1,198,500 | $1,206,756 | 96 | $15.1M | Research |
| Apple Caribe, INC | Accommodation and Food Services | $1,184,700 | $1,194,408 | 456 | $81.0M | Research |
| Almacenes Kress De Cayey, Inc. | Retail Trade | $1,174,900 | $1,188,085 | 390 | $118.0M | Research |