| Butler Marine INC | Retail Trade | $358,200 | $363,068 | 30 | $7.8M |  Research |
| Senior Health Associates | Health Care and Social Assistance | $355,757 | $360,552 | 26 | <$5M | Research |
| Ladys Island Dockside LLC | Accommodation and Food Services | $354,464 | $356,532 | 68 | $12.1M | Research |
| Gee Brothers & Dulaney, LLC | Accommodation and Food Services | $352,985 | $356,387 | 125 | $22.2M | Research |
| Howell Gibson & Hughes, PA | Professional, Scientific, and Technical Services | $341,017 | $343,641 | 16 | <$5M | Research |
| Global Building Contractors LLC | Construction | $332,647 | $334,816 | 14 | $16.0M | Research |
| Beaufort Pediatrics PA | Health Care and Social Assistance | $316,725 | $318,287 | 28 | $8.8M | Research |
| Allen Patterson Residential LLC | Construction | $310,992 | $312,747 | 36 | $10.9M | Research |
| Pro-Slab Inc. | Construction | $310,097 | $312,518 | 28 | $6.5M | Research |
| Allen Patterson Residential, LLC | Construction | $300,460 | $302,526 | 36 | $10.9M | Research |
| Carolina Sportscare & Physical Therapy, INC | Health Care and Social Assistance | $298,000 | $299,614 | 32 | $8.6M | Research |
| Factory Creek Al LLC | Health Care and Social Assistance | $293,925 | $298,007 | 66 | $11.2M | Research |
| Harvey & Battey, P.a. | Professional, Scientific, and Technical Services | $293,473 | $295,209 | 18 | <$5M | Research |
| Dust Solutions, Inc. | Manufacturing | $288,490 | $290,734 | 17 | <$5M | Research |
| Afrikan Alchemy LLC | Retail Trade | $286,447 | $0 | 16 | <$5M | Research |
| The Vestry and Church-Wardens of Episcopal Church Parish St. | Other Services (except Public Administration) | $274,900 | $231,791 | 20 | N/A | Research |
| 303 Associates, LLC | Real Estate and Rental and Leasing | $265,800 | $143,341 | 12 | <$5M | Research |
| Hmv Hotels LLC | Accommodation and Food Services | $252,798 | $255,305 | 30 | $9.4M | Research |
| Greenline Industries INC | Manufacturing | $250,000 | $252,438 | 30 | $29.8M | Research |
| Ladys Island Dockside, LLC | Accommodation and Food Services | $241,165 | $242,987 | 55 | $9.8M | Research |
| 822 Bay INC | Accommodation and Food Services | $224,170 | $225,454 | 25 | <$5M | Research |
| Poticha Restaurants L.l.c. | Accommodation and Food Services | $223,500 | $225,238 | 37 | $6.6M | Research |
| Pro-Slab Inc. | Construction | $219,200 | $220,761 | 40 | $9.3M | Research |
| Kintz Electric, LLC | Construction | $218,100 | $219,857 | 20 | $6.6M | Research |
| Jeffery M Reuben M.d., P.a. | Health Care and Social Assistance | $217,600 | $219,162 | 18 | $5.6M | Research |