| Furniture Warehouse Sales, Inc. | Retail Trade | $215,190 | $216,870 | 20 | <$5M |  Research |
| Global Building Contractors LLC | Construction | $211,997 | $213,536 | 13 | $14.8M | Research |
| Lowcountry Concrete of Ridgeland, INC | Manufacturing | $203,700 | $205,132 | 24 | $23.8M | Research |
| Poticha Restaurants L.l.c. | Accommodation and Food Services | $202,400 | $203,541 | 39 | $6.9M | Research |
| Athena Corporation | Construction | $196,000 | $197,062 | 22 | $6.9M | Research |
| Animal Hospital of Lady's Island, P.a. | Professional, Scientific, and Technical Services | $192,160 | $193,596 | 20 | <$5M | Research |
| O'quinn Marine Construction, Inc. | Construction | $191,605 | $192,965 | 19 | $5.9M | Research |
| Harris Pillow Supply, Inc. | Manufacturing | $187,577 | $188,774 | 32 | $11.3M | Research |
| Sea Island Pediatrics P.a | Health Care and Social Assistance | $186,904 | $188,691 | 13 | <$5M | Research |
| Hmv Hotels, LLC | Accommodation and Food Services | $184,100 | $186,632 | 40 | $12.5M | Research |
| Andrews Engineering Company Incorporated, the | Professional, Scientific, and Technical Services | $183,632 | $184,754 | 12 | <$5M | Research |
| Professiional Exteriors II LLC | Construction | $182,900 | $185,186 | 17 | <$5M | Research |
| The Eastern Westerner | Retail Trade | $182,000 | $0 | 7 | <$5M | Research |
| Griffith Freeman & Liipfert, LLC | Professional, Scientific, and Technical Services | $180,800 | $181,784 | 13 | <$5M | Research |
| Griffith Freeman & Liipfert LLC | Professional, Scientific, and Technical Services | $180,800 | $182,056 | 14 | <$5M | Research |
| Selectric, LLC | Construction | $180,000 | $181,011 | 23 | $7.6M | Research |
| Beaufort Orthopaedic Sports and Spine Center, LLC | Health Care and Social Assistance | $179,845 | $181,134 | 25 | $7.8M | Research |
| Wildcat Steel and Fabricating LLC | Manufacturing | $178,280 | $179,820 | 15 | <$5M | Research |
| Mims Mcduff & Wood PA | Professional, Scientific, and Technical Services | $177,500 | $179,212 | 13 | <$5M | Research |
| Mcdougall Lawfirm, LLC | Other Services (except Public Administration) | $174,800 | $153,691 | 9 | <$5M | Research |
| Town Center Inn LLC | Accommodation and Food Services | $172,295 | $173,249 | 25 | $7.8M | Research |
| Carolina Containers of Beaufort, LLC | Administrative and Support and Waste Management | $170,847 | $171,835 | 20 | <$5M | Research |
| Ocean Light Corporation | Construction | $170,100 | $171,144 | 18 | $5.9M | Research |
| Stone Soup LLC | Accommodation and Food Services | $170,094 | $170,942 | 20 | <$5M | Research |
| 822 Bay INC | Accommodation and Food Services | $166,400 | $168,328 | 40 | $7.1M | Research |