| Travis J Fiegle, Dmd, P.a. | Health Care and Social Assistance | $281,400 | $284,592 | 33 | $7.6M |  AI Deep Dive |
| 3 Reds INC | Unknown | $279,011 | $281,625 | 35 | N/A | AI Deep Dive |
| S&r Bluffton INC | Accommodation and Food Services | $274,700 | $276,417 | 30 | $5.3M | AI Deep Dive |
| Jordan Construction of Hilton Head Inc. | Construction | $274,105 | $277,775 | 21 | $6.5M | AI Deep Dive |
| The Dispensary LLC | Accommodation and Food Services | $269,500 | $272,697 | 46 | $8.2M | AI Deep Dive |
| Palmetto Medical Group | Health Care and Social Assistance | $267,163 | $260,582 | 26 | $8.2M | AI Deep Dive |
| T & S Management, Inc. | Accommodation and Food Services | $265,100 | $266,770 | 28 | <$5M | AI Deep Dive |
| Lowcountry Community Church of Beaufort Country Inc. | Other Services (except Public Administration) | $263,282 | $265,352 | 21 | N/A | AI Deep Dive |
| Ward Edwards, INC | Professional, Scientific, and Technical Services | $262,800 | $264,537 | 17 | <$5M | AI Deep Dive |
| Custom Audio Video LLC | Professional, Scientific, and Technical Services | $261,864 | $263,772 | 17 | <$5M | AI Deep Dive |
| Custom Audio Video LLC | Retail Trade | $261,863 | $263,413 | 20 | $6.1M | AI Deep Dive |
| Richard Best Custom Homes, Llc. | Construction | $258,000 | $259,510 | 20 | $6.1M | AI Deep Dive |
| Kinghorn Insurance Agency, LLC | Finance and Insurance | $253,100 | $255,469 | 23 | $11.8M | AI Deep Dive |
| Jameson's Carolina, INC | Accommodation and Food Services | $249,574 | $251,467 | 48 | $8.5M | AI Deep Dive |
| Simoneaux Electric INC | Construction | $245,400 | $247,009 | 22 | $7.2M | AI Deep Dive |
| Simoneaux Electric Inc. | Construction | $245,400 | $247,166 | 17 | $5.6M | AI Deep Dive |
| Housekeeping Services of Hilton Head LLC | Administrative and Support and Waste Management | $243,170 | $245,608 | 44 | $9.5M | AI Deep Dive |
| T & S Management INC | Accommodation and Food Services | $241,300 | $0 | 26 | <$5M | AI Deep Dive |
| Howell Chase Heating & Air INC | Construction | $237,900 | $240,464 | 18 | $6.1M | AI Deep Dive |
| Lux LLC | Other Services (except Public Administration) | $237,000 | $238,987 | 17 | <$5M | AI Deep Dive |
| Vaden Infiniti, Inc. | Retail Trade | $236,771 | $238,317 | 14 | <$5M | AI Deep Dive |
| Housekeeping Services of Hilton Head, LLC | Other Services (except Public Administration) | $236,300 | $238,545 | 32 | $6.1M | AI Deep Dive |
| Jrcl, Inc. DBA Paul Davis Carpet Cleaning | Administrative and Support and Waste Management | $234,100 | $235,641 | 26 | <$5M | AI Deep Dive |
| Lowcountry Day Preschool, Inc. | Health Care and Social Assistance | $231,600 | $232,837 | 38 | $6.2M | AI Deep Dive |
| Farm Bluffton LLC | Accommodation and Food Services | $231,343 | $233,444 | 25 | <$5M | AI Deep Dive |