| Palmetto Primary Care Physicians LLC | Health Care and Social Assistance | $5,228,100 | $5,287,400 | 500 | $156.9M |  Research |
| Ls3p Associates Ltd | Professional, Scientific, and Technical Services | $4,898,700 | $4,961,431 | 335 | $103.9M | Research |
| Carolina Eastern INC | Agriculture, Forestry, Fishing and Hunting | $4,680,300 | $4,732,232 | 466 | $47.6M | Research |
| Mvp Group International, Inc. | Manufacturing | $4,575,262 | $4,418,701 | 349 | $97.4M | Research |
| The Porter Academy DBA Porter Gaud | Educational Services | $3,658,800 | $3,700,266 | 275 | N/A | Research |
| Rohoho, Inc. | Retail Trade | $3,514,400 | $3,554,620 | 500 | $55.5M | Research |
| Keystone Business Advisory Services, LLC | Construction | $3,445,000 | $3,937,323 | 261 | $80.9M | Research |
| Charleston Ent Associates, LLC | Health Care and Social Assistance | $3,226,900 | $3,265,888 | 288 | $90.4M | Research |
| Energy One America LLC | Construction | $3,048,700 | $3,084,607 | 233 | $58.9M | Research |
| Bishop of Charleston | Other Services (except Public Administration) | $3,033,297 | $0 | 268 | N/A | Research |
| Vdv Management Company LLC | Manufacturing | $3,030,200 | $3,064,902 | 466 | $130.1M | Research |
| George Sink, P.a. Injury Lawyers | Professional, Scientific, and Technical Services | $2,974,515 | $3,008,742 | 236 | $57.3M | Research |
| Coastal Pediatric Associates PA | Health Care and Social Assistance | $2,619,100 | $2,467,767 | 148 | $46.5M | Research |
| Avocet Hospitality Group INC | Accommodation and Food Services | $2,515,076 | $220,496 | 297 | $92.9M | Research |
| Bishop Gadsen Episcopal Retirement Community | Health Care and Social Assistance | $2,368,048 | $2,395,346 | 380 | $64.6M | Research |
| Ashley Hall Foundation | Educational Services | $2,208,777 | $2,260,376 | 175 | N/A | Research |
| Halls Southern Kitchens LLC | Accommodation and Food Services | $2,074,500 | $2,104,638 | 289 | $51.3M | Research |
| Charleston Oncology, P.a. | Health Care and Social Assistance | $2,074,100 | $0 | 162 | $50.8M | Research |
| Library Associates, LLC | Information | $2,053,500 | $2,076,848 | 312 | $52.4M | Research |
| Charleston Ent Associates LLC | Health Care and Social Assistance | $2,000,000 | $2,019,836 | 288 | $90.4M | Research |
| Library Associates LLC | Accommodation and Food Services | $2,000,000 | $2,015,781 | 243 | $76.0M | Research |
| Coastal Pediatric Associates PA | Health Care and Social Assistance | $2,000,000 | $2,016,556 | 170 | $53.4M | Research |
| Dewberry 334 Meeting Street LLC | Accommodation and Food Services | $2,000,000 | $1,958,330 | 88 | $27.5M | Research |
| Ashley Hall Foundation | Educational Services | $2,000,000 | $2,030,222 | 160 | N/A | Research |
| Halls Southern Kitchens LLC | Accommodation and Food Services | $2,000,000 | $2,032,333 | 272 | $48.3M | Research |