| Jd Motorsports | Arts, Entertainment, and Recreation | $252,100 | $123,900 | 33 | $5.4M | Research |
| Hackel Sc Entertainment LLC | Information | $221,755 | $223,663 | 43 | $7.2M | Research |
| Hackel Sc Entertainment | Arts, Entertainment, and Recreation | $220,260 | $222,251 | 33 | $5.4M | Research |
| Double R Utilities INC | Administrative and Support and Waste Management | $214,300 | $216,264 | 22 | <$5M | Research |
| Gaffney Buick Gmc | Retail Trade | $213,400 | $215,415 | 21 | $5.3M | Research |
| Piping & Maintenance Contractors, Inc. | Other Services (except Public Administration) | $210,535 | $209,172 | 21 | <$5M | Research |
| Moderna Products America, LLC | Manufacturing | $197,678 | $199,979 | 31 | $30.7M | Research |
| Wright Enterprises and Associates LLC | Administrative and Support and Waste Management | $191,900 | $193,974 | 46 | $8.7M | Research |
| Peachy Poultry, Inc. | Accommodation and Food Services | $184,900 | $186,035 | 45 | $8.0M | Research |
| Cline Brandt Kochenower Co PA | Professional, Scientific, and Technical Services | $176,500 | $178,098 | 15 | <$5M | Research |
| Rug & Home Inc. | Retail Trade | $170,700 | $171,606 | 22 | <$5M | Research |
| Rug & Home Inc. | Retail Trade | $167,100 | $168,382 | 22 | <$5M | Research |
| Physical Therapy Inc. | Health Care and Social Assistance | $160,500 | $161,208 | 10 | <$5M | Research |
| Physical Therapy, Inc. | Health Care and Social Assistance | $160,500 | $161,648 | 10 | <$5M | Research |
| Lemaster Livestock, Inc. | Agriculture, Forestry, Fishing and Hunting | $158,600 | $159,904 | 18 | <$5M | Research |
| B&b Inc. of Gaffney Sc | Construction | $157,602 | $158,552 | 19 | $5.9M | Research |
| Porters Electric Motor Service, Inc. | Wholesale Trade | $156,910 | $159,176 | 15 | <$5M | Research |
| B&b Inc. of Gaffney Sc | Construction | $154,632 | $155,573 | 18 | $5.6M | Research |
| Mr. Waffle of Gaffney Inc. | Accommodation and Food Services | $143,871 | $144,423 | 22 | <$5M | Research |
| Cherokee General Dentistry PA | Health Care and Social Assistance | $143,430 | $144,110 | 14 | <$5M | Research |
| First Baptist Church of Gaffney, Sc, Inc. | Other Services (except Public Administration) | $134,605 | $135,818 | 25 | N/A | Research |
| Rg Burns INC | Other Services (except Public Administration) | $134,280 | $135,384 | 17 | <$5M | Research |
| Mason and Wright INC DBA Mcdonalds | Accommodation and Food Services | $132,300 | $133,131 | 36 | $6.4M | Research |
| Cherokee County Family Ymca | Other Services (except Public Administration) | $131,900 | $132,482 | 35 | N/A | Research |
| Cherokee County Family Ymca | Other Services (except Public Administration) | $131,900 | $132,605 | 38 | N/A | Research |