| Quality Auto Sales of Hartsville | Wholesale Trade | $270,700 | $273,533 | 25 | $7.7M | AI Deep Dive |
| Jbe INC | Transportation and Warehousing | $266,247 | $269,063 | 35 | $8.9M | AI Deep Dive |
| Humphrey Coker Seed Company | Agriculture, Forestry, Fishing and Hunting | $251,092 | $253,555 | 73 | <$5M | AI Deep Dive |
| Dawkins Concrete Products | Manufacturing | $242,800 | $246,026 | 33 | $32.7M | AI Deep Dive |
| Hartsville Medical Associates LLC | Health Care and Social Assistance | $239,800 | $243,262 | 43 | $13.5M | AI Deep Dive |
| Humphrey Coker Seed Co | Agriculture, Forestry, Fishing and Hunting | $229,400 | $231,650 | 23 | <$5M | AI Deep Dive |
| Anderson Plumbing & Indsutrial INC | Construction | $210,385 | $211,560 | 23 | $7.3M | AI Deep Dive |
| Morphis Pediatric Group of Hartsville | Health Care and Social Assistance | $192,364 | $194,166 | 17 | $5.3M | AI Deep Dive |
| Morphis Pediatric Group, Hartsville | Health Care and Social Assistance | $192,300 | $193,812 | 22 | $6.9M | AI Deep Dive |
| Young Mens Christian Association of the Upper Pee Dee | Other Services (except Public Administration) | $191,842 | $193,280 | 114 | N/A | AI Deep Dive |
| Young Mens Christian Association of the Upper Pee Dee | Arts, Entertainment, and Recreation | $191,840 | $192,916 | 114 | N/A | AI Deep Dive |
| Pine Tree Hill Al LLC | Health Care and Social Assistance | $191,435 | $194,110 | 35 | $6.0M | AI Deep Dive |
| Shoney's of Hartsville Inc. | Accommodation and Food Services | $190,350 | $192,280 | 23 | <$5M | AI Deep Dive |
| Hartsville Family Dentistry Associates INC | Health Care and Social Assistance | $180,700 | $182,160 | 17 | <$5M | AI Deep Dive |
| Hartsville Family Dentistry Associates | Health Care and Social Assistance | $180,100 | $181,263 | 17 | <$5M | AI Deep Dive |
| Noc Home Care LLC | Health Care and Social Assistance | $178,187 | $179,370 | 72 | $12.3M | AI Deep Dive |
| The Children's Group P.c. | Health Care and Social Assistance | $176,400 | $177,700 | 18 | $5.6M | AI Deep Dive |
| Chafin, Johnson & Associates, LLC | Professional, Scientific, and Technical Services | $176,300 | $157,739 | 7 | <$5M | AI Deep Dive |
| The Children's Group P.c. | Health Care and Social Assistance | $176,000 | $177,162 | 19 | $6.0M | AI Deep Dive |
| Gold Leaf Seed Co, INC | Agriculture, Forestry, Fishing and Hunting | $175,920 | $145,998 | 8 | <$5M | AI Deep Dive |
| Impact Imaging Group[ LLC | Professional, Scientific, and Technical Services | $169,200 | $170,225 | 16 | <$5M | AI Deep Dive |
| Mka Mechanical | Construction | $163,100 | $164,123 | 15 | <$5M | AI Deep Dive |
| S and S Insulation LLC | Construction | $162,957 | $165,225 | 7 | <$5M | AI Deep Dive |
| Mka Mechanical Inc. | Construction | $162,672 | $163,835 | 16 | $5.1M | AI Deep Dive |
| Sk Hartsville LLC | Accommodation and Food Services | $162,169 | $163,318 | 40 | $7.1M | AI Deep Dive |