| Hudson Seafood Corporation | Accommodation and Food Services | $872,470 | $886,685 | 94 | $16.7M |  Research |
| Long Cove Club Owners Association, Inc. | Real Estate and Rental and Leasing | $837,032 | $842,287 | 82 | $15.0M | Research |
| Coastal Employment, INC | Administrative and Support and Waste Management | $823,100 | $829,708 | 137 | $21.6M | Research |
| Argents Air Express Ltd. | Professional, Scientific, and Technical Services | $762,223 | $768,596 | 67 | $6.9M | Research |
| Rolling Dough LLC | Accommodation and Food Services | $760,700 | $769,892 | 164 | $29.1M | Research |
| Elite Resort Group, Inc. | Accommodation and Food Services | $752,200 | $759,053 | 72 | $22.5M | Research |
| Hhb&t Convention Center Inc. | Real Estate and Rental and Leasing | $749,885 | $759,363 | 61 | $9.2M | Research |
| Reilley's of Hilton Head Ltd | Accommodation and Food Services | $710,800 | $716,486 | 70 | $12.4M | Research |
| Shoogie Shack LLC | Accommodation and Food Services | $710,100 | $714,933 | 67 | $11.9M | Research |
| Hilton Head Hospitality, LLC | Accommodation and Food Services | $703,100 | $708,529 | 95 | $29.7M | Research |
| Hhb&t Convention Center INC | Other Services (except Public Administration) | $692,412 | $699,721 | 75 | $14.3M | Research |
| Hilton Head Christian Academy | Educational Services | $692,340 | $696,725 | 123 | N/A | Research |
| Skull Creek Partners, LLC | Accommodation and Food Services | $671,100 | $675,609 | 95 | $16.9M | Research |
| H3 Hilton Head, LLC | Other Services (except Public Administration) | $658,900 | $662,615 | 63 | $12.0M | Research |
| Camp Partners LLC | Accommodation and Food Services | $648,300 | $653,721 | 57 | $10.1M | Research |
| Skull Creek Dockside LLC | Accommodation and Food Services | $640,300 | $644,533 | 68 | $12.1M | Research |
| J. Banks Design Group, Inc. | Professional, Scientific, and Technical Services | $629,790 | $633,899 | 60 | $13.9M | Research |
| J Banks Design Group Inc. | Professional, Scientific, and Technical Services | $629,790 | $633,061 | 37 | $8.6M | Research |
| Hilton Head Hospitality | Real Estate and Rental and Leasing | $621,272 | $627,295 | 107 | $19.6M | Research |
| Scott Gochnauer, Inc. | Other Services (except Public Administration) | $617,500 | $619,868 | 61 | $11.7M | Research |
| Windsurfing Hilton Head INC | Arts, Entertainment, and Recreation | $613,419 | $621,453 | 70 | $9.8M | Research |
| Ocean Woods Landscaping Co., Inc. | Administrative and Support and Waste Management | $609,000 | $614,380 | 84 | $18.2M | Research |
| Ocean Woods Landscaping Co INC | Administrative and Support and Waste Management | $593,900 | $597,562 | 43 | $9.3M | Research |
| Imc Resort Services, Inc. | Real Estate and Rental and Leasing | $586,700 | $590,514 | 55 | $8.3M | Research |
| Browndog Inc. | Accommodation and Food Services | $582,200 | $590,076 | 80 | $14.2M | Research |