| Best Western Three D Inn Inc. | Accommodation and Food Services | $263,081 | $266,656 | 35 | $10.9M |  AI Deep Dive |
| Santee Cooper Resort | Arts, Entertainment, and Recreation | $224,691 | $225,652 | 78 | $10.9M | AI Deep Dive |
| Talley Mfg., Inc. | Manufacturing | $214,885 | $216,353 | 23 | $5.6M | AI Deep Dive |
| Clark's Restaurant Corporation | Accommodation and Food Services | $210,856 | $212,344 | 32 | $5.7M | AI Deep Dive |
| Captain's Quarters LLC | Accommodation and Food Services | $207,602 | $209,199 | 20 | <$5M | AI Deep Dive |
| Mid Carolina Pipe and Maintenance Inc. | Administrative and Support and Waste Management | $189,000 | $154,574 | 18 | <$5M | AI Deep Dive |
| Best Western Three D Inn, Inc. | Accommodation and Food Services | $187,915 | $189,640 | 39 | $12.2M | AI Deep Dive |
| Magnolias of Santee | Health Care and Social Assistance | $160,520 | $161,835 | 36 | $6.1M | AI Deep Dive |
| Party City of Charleston, Inc. | Retail Trade | $149,500 | $150,561 | 11 | <$5M | AI Deep Dive |
| Captain's Quarters, LLC | Accommodation and Food Services | $148,287 | $149,453 | 36 | $6.4M | AI Deep Dive |
| H I of Santee INC | Accommodation and Food Services | $148,021 | $170,630 | 43 | $13.4M | AI Deep Dive |
| Tyvola Inn LLC | Accommodation and Food Services | $127,040 | $181,205 | 29 | $9.1M | AI Deep Dive |
| Cedar Communities at Santee, LLC | Health Care and Social Assistance | $123,662 | $125,290 | 40 | $6.8M | AI Deep Dive |
| Party City of Savannah, Inc. | Retail Trade | $121,400 | $122,173 | 25 | $5.4M | AI Deep Dive |
| F I of Santee, LLC | Accommodation and Food Services | $120,913 | $121,994 | 34 | $10.6M | AI Deep Dive |
| H.i. of Santee, Inc. | Accommodation and Food Services | $119,773 | $119,670 | 35 | $10.9M | AI Deep Dive |
| Santee Management, Inc. | Professional, Scientific, and Technical Services | $93,678 | $94,523 | 7 | <$5M | AI Deep Dive |
| Santee Wire Products, INC | Manufacturing | $90,799 | $91,621 | 7 | <$5M | AI Deep Dive |
| Santee Animal Hospital, LLC | Professional, Scientific, and Technical Services | $87,570 | $88,290 | 13 | <$5M | AI Deep Dive |
| Gauri LLC | Accommodation and Food Services | $84,826 | $85,220 | 19 | $5.9M | AI Deep Dive |
| Clark's Restaurant Corp. | Accommodation and Food Services | $84,031 | $84,745 | 60 | $10.7M | AI Deep Dive |
| Prammish LLC | Accommodation and Food Services | $82,306 | $82,729 | 35 | $10.9M | AI Deep Dive |
| Sigmatex Carbon Textile Solutions | Manufacturing | $79,000 | $79,830 | 6 | <$5M | AI Deep Dive |
| Clark's Motel Inc. | Accommodation and Food Services | $75,967 | $76,602 | 12 | <$5M | AI Deep Dive |
| Prammish, LLC | Accommodation and Food Services | $72,792 | $73,393 | 28 | $8.8M | AI Deep Dive |