| Montreux LLC | Accommodation and Food Services | $371,200 | $374,668 | 44 | $7.8M |  Research |
| Charleston Endodontics LLC | Health Care and Social Assistance | $367,717 | $371,159 | 26 | $6.0M | Research |
| H & J Contracting of Sc LLC | Construction | $353,270 | $355,303 | 30 | $11.2M | Research |
| Charleston Endodontics PA | Health Care and Social Assistance | $335,000 | $336,759 | 31 | $7.2M | Research |
| Nextgen Technologies Inc. | Public Administration | $330,300 | $286,349 | 22 | N/A | Research |
| Murray Sand Co. Inc. | Transportation and Warehousing | $327,200 | $330,544 | 25 | $6.7M | Research |
| Sfd Carnes LLC | Health Care and Social Assistance | $326,300 | $329,313 | 28 | $6.5M | Research |
| Tideland Utilities, INC | Construction | $326,100 | $330,448 | 30 | $9.3M | Research |
| Sfd Carnes LLC | Health Care and Social Assistance | $321,500 | $323,623 | 41 | $9.5M | Research |
| Coastal Millwork & Supply, LLC | Construction | $320,500 | $322,699 | 33 | $10.4M | Research |
| Coastal Millwork & Supply LLC | Manufacturing | $320,067 | $322,636 | 31 | $30.7M | Research |
| Mjd Enterprises, Inc. | Accommodation and Food Services | $318,400 | $321,319 | 39 | $6.9M | Research |
| Upstairs at the Icehouse, Inc. | Accommodation and Food Services | $315,900 | $319,526 | 72 | $12.8M | Research |
| Horizon Landscape Management LLC | Administrative and Support and Waste Management | $314,129 | $316,253 | 32 | $6.9M | Research |
| The Kasen Law Firm Pllc | Professional, Scientific, and Technical Services | $307,740 | $309,806 | 27 | $6.6M | Research |
| Palmetto Landscape & Design, LLC | Professional, Scientific, and Technical Services | $307,500 | $310,592 | 43 | $8.7M | Research |
| Bethany United Methodist Church of Summerville INC | Other Services (except Public Administration) | $307,200 | $310,161 | 102 | N/A | Research |
| Port City Transport & Logistics LLC | Transportation and Warehousing | $299,133 | $0 | 24 | <$5M | Research |
| Reads Moving Systems of Carolina | Transportation and Warehousing | $298,400 | $300,133 | 40 | $6.0M | Research |
| Reads Moving Systems of Carolina | Transportation and Warehousing | $298,400 | $300,231 | 40 | $10.0M | Research |
| Charleston Sports Pub 2 LLC | Accommodation and Food Services | $297,000 | $298,603 | 40 | $7.1M | Research |
| Nextgen Technologies, Inc. | Administrative and Support and Waste Management | $294,500 | $297,110 | 24 | <$5M | Research |
| Mills Investments LLC | Accommodation and Food Services | $293,000 | $295,713 | 115 | $20.4M | Research |
| Driggers Small Engine INC | Other Services (except Public Administration) | $291,100 | $294,561 | 31 | $6.1M | Research |
| Summerville Pw LLC | Retail Trade | $290,500 | $293,413 | 91 | $22.7M | Research |