| Sc House Calls, Inc. | Health Care and Social Assistance | $4,341,086 | $4,453,122 | 421 | $72.1M |  Research |
| Dmac81, LLC | Accommodation and Food Services | $4,004,200 | $3,452,970 | 500 | $88.8M | Research |
| South Carolina Episcopal Home at Still Hopes | Health Care and Social Assistance | $2,798,305 | $2,835,335 | 498 | N/A | Research |
| Palmetto Automatic Sprinkler Co, Inc. | Construction | $2,596,000 | $2,625,998 | 265 | $83.8M | Research |
| Sd-2 LLC | Accommodation and Food Services | $2,430,600 | $2,201,915 | 354 | $62.9M | Research |
| Total Comfort Solutions, Inc. | Construction | $2,104,000 | $2,137,135 | 148 | $46.8M | Research |
| Sd-2 LLC | Accommodation and Food Services | $2,000,000 | $2,016,889 | 300 | $53.3M | Research |
| Dmac81 LLC | Accommodation and Food Services | $2,000,000 | $2,018,222 | 300 | $53.3M | Research |
| Rush's Food Systems INC | Accommodation and Food Services | $1,871,600 | $1,894,931 | 409 | $72.6M | Research |
| The Marwin Company, Inc. | Manufacturing | $1,818,500 | $1,835,826 | 203 | $201.3M | Research |
| Worldwide Equipment of South Carolina, INC | Wholesale Trade | $1,611,547 | $1,635,719 | 132 | $40.4M | Research |
| Triad Enterprises INC | Manufacturing | $1,597,017 | $1,614,895 | 121 | $120.0M | Research |
| Anderson Columbia, LLC | Retail Trade | $1,298,200 | $1,070,544 | 95 | $23.9M | Research |
| Intramed Plus, INC | Retail Trade | $1,279,200 | $1,296,682 | 100 | $17.5M | Research |
| Southern Development Management Company, INC | Real Estate and Rental and Leasing | $1,238,100 | $1,245,013 | 147 | $22.1M | Research |
| Carolina Care, P.a. | Health Care and Social Assistance | $1,208,300 | $1,219,357 | 58 | $18.2M | Research |
| Sun, Inc. | Manufacturing | $1,122,998 | $1,131,170 | 85 | $84.3M | Research |
| Consutants in Gastroenterology PA | Health Care and Social Assistance | $1,090,000 | $1,098,387 | 83 | $26.1M | Research |
| United Cerebral Palsy of South Carolina INC | Health Care and Social Assistance | $1,082,700 | $1,088,595 | 100 | N/A | Research |
| Consultants in Gastroenterology PA | Health Care and Social Assistance | $1,055,954 | $1,062,055 | 74 | $23.2M | Research |
| Eagle Aviation, Inc. | Administrative and Support and Waste Management | $1,046,038 | $1,059,956 | 108 | $20.4M | Research |
| Eagle Aviation Inc. | Transportation and Warehousing | $1,007,795 | $1,019,357 | 101 | $7.9M | Research |
| Harris Integrated Solutions INC | Wholesale Trade | $957,896 | $965,323 | 58 | $17.8M | Research |
| Msi Construction INC | Construction | $940,935 | $945,446 | 77 | $87.7M | Research |
| Msi Construction INC | Construction | $940,935 | $946,658 | 68 | $77.5M | Research |