| Brown & Associates Home Health Services, INC | Health Care and Social Assistance | $478,465 | $481,428 | 163 | $27.9M |  Research |
| Consolidated Mailing Services, LLC | Administrative and Support and Waste Management | $476,513 | $325,864 | 44 | $8.3M | Research |
| Kwon LLC | Accommodation and Food Services | $469,945 | $475,687 | 59 | $7.2M | Research |
| Physical Rehabilitation Group LLC | Health Care and Social Assistance | $440,713 | $443,164 | 44 | $11.9M | Research |
| White Crane Company, Inc. | Real Estate and Rental and Leasing | $434,000 | $437,888 | 24 | $10.8M | Research |
| Ams of West Columbia, INC | Health Care and Social Assistance | $430,536 | $441,648 | 53 | $12.3M | Research |
| Strategic Staffing LLC | Administrative and Support and Waste Management | $430,500 | $435,690 | 36 | $5.7M | Research |
| Strategic Staffing LLC | Administrative and Support and Waste Management | $430,500 | $436,479 | 129 | $20.3M | Research |
| Cafe Strudels LLC | Accommodation and Food Services | $425,694 | $430,105 | 53 | $9.4M | Research |
| Michael's Cafe and Catering LLC | Accommodation and Food Services | $406,747 | $414,180 | 39 | $6.9M | Research |
| W. C. Manufacturing & Specialty Co. Inc. | Manufacturing | $386,200 | $387,787 | 72 | $18.9M | Research |
| Palmetto Design Associates, INC | Construction | $385,300 | $279,411 | 20 | $6.1M | Research |
| Palmetto Dermatology, P.a. | Health Care and Social Assistance | $379,095 | $381,391 | 26 | $8.2M | Research |
| Sox and Sons Construction Company Inc. | Construction | $372,869 | $377,633 | 40 | $12.4M | Research |
| Hands and Hearts Home Care LLC | Health Care and Social Assistance | $371,185 | $373,236 | 153 | $26.2M | Research |
| Pressure Pros INC | Construction | $365,152 | $368,702 | 78 | $26.6M | Research |
| Pressure Pros, INC | Administrative and Support and Waste Management | $365,100 | $369,841 | 32 | $6.9M | Research |
| Mermec Inc. | Manufacturing | $356,105 | $358,529 | 25 | $6.5M | Research |
| Mermec INC | Manufacturing | $356,100 | $357,960 | 18 | <$5M | Research |
| Jumper, Carter & Sease Architects, PA | Professional, Scientific, and Technical Services | $341,147 | $344,198 | 22 | $6.8M | Research |
| Kwon, LLC | Accommodation and Food Services | $340,586 | $282,614 | 60 | $7.3M | Research |
| Grace Baptist Church of West Columbia, Sc | Other Services (except Public Administration) | $326,300 | $328,472 | 60 | N/A | Research |
| Becker Complete Compactor | Other Services (except Public Administration) | $318,800 | $321,219 | 26 | $5.6M | Research |
| The Manos Zesto Company, LLC | Accommodation and Food Services | $318,614 | $322,597 | 86 | $15.3M | Research |
| W. C. Manufacturing & Specialty Co., Inc. | Manufacturing | $314,200 | $315,827 | 56 | $14.7M | Research |