| Severino Sanchez Jr. INC | Transportation and Warehousing | $217,153 | $218,688 | 26 | $5.2M | AI Deep Dive |
| James O. Baker | Accommodation and Food Services | $196,591 | $197,631 | 27 | <$5M | AI Deep Dive |
| Sentry Security Service, LLC | Administrative and Support and Waste Management | $185,303 | $186,430 | 18 | <$5M | AI Deep Dive |
| Delgado's Contractors LLC | Construction | $181,535 | $182,614 | 27 | $9.2M | AI Deep Dive |
| Muller Textiles INC | Manufacturing | $180,635 | $183,922 | 8 | <$5M | AI Deep Dive |
| Sunset Memorial Oaks Funeral H | Other Services (except Public Administration) | $176,700 | $179,977 | 34 | $6.5M | AI Deep Dive |
| Krkl & Co LLC | Accommodation and Food Services | $175,667 | $176,572 | 35 | $6.2M | AI Deep Dive |
| 5248 N 10th LLC | Accommodation and Food Services | $175,486 | $176,515 | 39 | $6.9M | AI Deep Dive |
| Del Rio Management Co LLC | Accommodation and Food Services | $175,000 | $176,688 | 35 | $6.2M | AI Deep Dive |
| Border Opportunity Saver Systems, INC | Manufacturing | $172,913 | $174,225 | 27 | $7.5M | AI Deep Dive |
| Tra Transports LLC | Transportation and Warehousing | $168,721 | $170,358 | 28 | $10.8M | AI Deep Dive |
| Magico Logistics LLC | Transportation and Warehousing | $163,300 | $165,340 | 17 | <$5M | AI Deep Dive |
| Southwest Assisted Living - Del Rio LLC | Health Care and Social Assistance | $159,500 | $161,663 | 49 | $8.3M | AI Deep Dive |
| Premier Plastics (del Rio) Inc. | Manufacturing | $159,000 | $160,163 | 32 | $31.7M | AI Deep Dive |
| Amistad Industries Ltd | Real Estate and Rental and Leasing | $152,100 | $153,742 | 20 | <$5M | AI Deep Dive |
| Premier Plastics (del Rio) Inc. | Manufacturing | $151,562 | $152,791 | 32 | $31.7M | AI Deep Dive |
| Southwest Assisted Living-Del Rio, LLC | Health Care and Social Assistance | $150,700 | $152,711 | 33 | $5.6M | AI Deep Dive |
| Tra Transports LLC | Transportation and Warehousing | $150,000 | $150,777 | 21 | $8.1M | AI Deep Dive |
| Kusy Ventures, Ltd | Accommodation and Food Services | $147,932 | $149,249 | 37 | $6.6M | AI Deep Dive |
| Russell Hardware, INC | Retail Trade | $145,000 | $145,663 | 22 | <$5M | AI Deep Dive |
| Manuel's Steakhouse LLC | Accommodation and Food Services | $144,889 | $145,766 | 16 | <$5M | AI Deep Dive |
| Union Slaughter House INC | Manufacturing | $143,500 | $144,440 | 37 | $13.1M | AI Deep Dive |
| Gatti's Pizza | Accommodation and Food Services | $140,422 | $141,553 | 25 | <$5M | AI Deep Dive |
| M.r. Frankie, Inc. | Accommodation and Food Services | $139,340 | $140,252 | 20 | <$5M | AI Deep Dive |
| Khoury Hyundai of Del Rio, INC | Retail Trade | $137,600 | $138,594 | 18 | <$5M | AI Deep Dive |