| Texas Visiting Nurse Service Ltd | Health Care and Social Assistance | $6,214,693 | $6,294,037 | 500 | $85.6M |  Research |
| Su Clinica Familiar | Health Care and Social Assistance | $3,558,600 | $3,611,540 | 383 | N/A | Research |
| Agua Cristalina Home Care LLC | Health Care and Social Assistance | $2,059,600 | $2,006,629 | 500 | $85.6M | Research |
| Santa Cruz Health Services Inc. | Health Care and Social Assistance | $1,671,900 | $1,687,016 | 344 | $58.9M | Research |
| Amaru Motors LP | Retail Trade | $1,458,200 | $1,472,343 | 153 | $38.6M | Research |
| Marine Military Academy INC | Educational Services | $1,376,430 | $1,336,330 | 169 | N/A | Research |
| Valley View Primary Home Care | Health Care and Social Assistance | $1,191,700 | $1,206,729 | 435 | $74.5M | Research |
| Bert Ogden Harlingen Motors, Inc. | Retail Trade | $1,067,790 | $1,079,150 | 78 | $19.7M | Research |
| Valley Solvent Company, Inc. | Wholesale Trade | $1,035,700 | $1,043,759 | 91 | $23.4M | Research |
| Fiesta Harlingen Motors, Inc. | Retail Trade | $1,034,804 | $1,045,813 | 68 | $17.1M | Research |
| Paradigm Health Management Corp | Health Care and Social Assistance | $996,700 | $1,010,626 | 230 | $39.4M | Research |
| Access Dental of Harlingen Pllc | Health Care and Social Assistance | $996,500 | $1,000,901 | 193 | $44.7M | Research |
| Juan D. Villarreal, Dds, Series Pllc | Health Care and Social Assistance | $996,500 | $0 | 193 | $44.7M | Research |
| Juan D Villarreal DDS Series Pllc | Health Care and Social Assistance | $967,125 | $975,074 | 125 | $29.0M | Research |
| December Nine Company, Ltd. | Other Services (except Public Administration) | $958,600 | $967,653 | 197 | $37.6M | Research |
| Central Air and Heating Service Inc. | Construction | $957,640 | $962,966 | 91 | $28.8M | Research |
| Central Air & Heating Service INC | Construction | $957,640 | $965,327 | 91 | $28.8M | Research |
| South Texas Emergency Care Foundation Inc. | Health Care and Social Assistance | $950,100 | $958,612 | 76 | N/A | Research |
| All Texas Health Care, Inc. | Health Care and Social Assistance | $945,618 | $955,437 | 375 | $64.2M | Research |
| Sunglo Home Health Services, INC | Health Care and Social Assistance | $938,100 | $948,914 | 277 | $47.4M | Research |
| South Texas Emergency Care Foundation Inc. | Health Care and Social Assistance | $936,800 | $942,857 | 73 | N/A | Research |
| Medic Home Care, INC | Health Care and Social Assistance | $863,000 | $875,274 | 275 | $47.1M | Research |
| Valley Aids Council | Health Care and Social Assistance | $860,000 | $866,092 | 100 | N/A | Research |
| Synctx LLC | Transportation and Warehousing | $817,469 | $0 | 172 | $40.1M | Research |
| Boggus Motor Company II LLC | Retail Trade | $791,420 | $802,016 | 100 | $25.2M | Research |