| Valley Cancer Associates PA | Health Care and Social Assistance | $744,600 | $751,577 | 70 | $22.0M |  Research |
| Hands of Angels Home Care INC | Health Care and Social Assistance | $733,100 | $739,331 | 320 | $54.8M | Research |
| Reveille Trucking INC | Transportation and Warehousing | $730,690 | $736,088 | 88 | $17.7M | Research |
| South Heart Clinic Pllc | Health Care and Social Assistance | $699,368 | $703,272 | 73 | $22.9M | Research |
| Tri County Kids Care LLC | Health Care and Social Assistance | $691,395 | $697,722 | 99 | $16.0M | Research |
| Ophthalmic Consultants of Texas PA | Health Care and Social Assistance | $662,500 | $669,199 | 53 | $16.6M | Research |
| Valley Coop Oil Mill | Manufacturing | $659,905 | $664,280 | 66 | $23.3M | Research |
| Datalogic Software, INC | Information | $649,700 | $657,265 | 46 | $7.7M | Research |
| Saldana Supply Co., L.l.c. | Professional, Scientific, and Technical Services | $635,387 | $341,628 | 64 | $9.0M | Research |
| South Heart Clinic Pllc | Health Care and Social Assistance | $595,162 | $598,832 | 68 | $21.3M | Research |
| Discount Title Loan Management Group LLC | Finance and Insurance | $593,622 | $596,761 | 57 | $29.3M | Research |
| Valley Baptist Ambulatory Surgery Center LLC | Health Care and Social Assistance | $570,800 | $574,336 | 58 | $10.3M | Research |
| Valley Baptist Ambulatory Surgery Center LLC | Health Care and Social Assistance | $556,200 | $563,940 | 58 | $18.2M | Research |
| Valley International Cold Storage, LLC | Transportation and Warehousing | $534,610 | $539,649 | 167 | $42.4M | Research |
| Valley Aids Council | Other Services (except Public Administration) | $529,800 | $533,509 | 115 | N/A | Research |
| Oil Patch Fuel & Supply, Inc. | Wholesale Trade | $495,500 | $501,473 | 59 | $15.2M | Research |
| Circle a Xpress INC | Information | $485,500 | $0 | 30 | $5.0M | Research |
| Home Health Solutions | Health Care and Social Assistance | $447,115 | $451,268 | 123 | $19.9M | Research |
| Jlw Home Health INC | Health Care and Social Assistance | $443,977 | $446,259 | 44 | $7.5M | Research |
| Aloe Laboratories, Inc. | Other Services (except Public Administration) | $443,841 | $447,638 | 57 | $10.9M | Research |
| Home Health Solutions | Health Care and Social Assistance | $443,017 | $446,828 | 130 | $22.3M | Research |
| South Texas Nursing INC | Health Care and Social Assistance | $434,300 | $438,173 | 140 | $22.7M | Research |
| South Texas Nursing INC | Health Care and Social Assistance | $434,300 | $439,886 | 122 | $19.8M | Research |
| Rocklake Insurance Group INC | Finance and Insurance | $425,685 | $428,053 | 48 | $21.1M | Research |
| Rio Roofing Inc. | Construction | $424,845 | $427,091 | 49 | $16.2M | Research |