| Robert Powers | Construction | $50,280 | $50,561 | 10 | <$5M | AI Deep Dive |
| Wise County Ah, Inc. | Professional, Scientific, and Technical Services | $49,500 | $49,808 | 7 | <$5M | AI Deep Dive |
| Appalachian Electrical Contractors | Construction | $49,500 | $49,983 | 9 | <$5M | AI Deep Dive |
| Creative Curb Appeal, Inc. | Administrative and Support and Waste Management | $48,700 | $49,026 | 10 | <$5M | AI Deep Dive |
| Kerry Hay Law Office, P.c. | Professional, Scientific, and Technical Services | $46,500 | $46,804 | 7 | <$5M | AI Deep Dive |
| Xperior Billing LLC | Professional, Scientific, and Technical Services | $45,000 | $45,492 | 10 | <$5M | AI Deep Dive |
| Cornerstone Pharmacy LLC | Retail Trade | $44,900 | $45,173 | 9 | <$5M | AI Deep Dive |
| Roma's LLC | Accommodation and Food Services | $43,300 | $43,657 | 11 | <$5M | AI Deep Dive |
| Wise Lumber & Supply Company, INC | Wholesale Trade | $41,800 | $42,268 | 15 | <$5M | AI Deep Dive |
| Wise Energy Group LLC | Professional, Scientific, and Technical Services | $41,770 | $42,048 | 3 | <$5M | AI Deep Dive |
| A & R Scrub-A-Dub Inc. | Other Services (except Public Administration) | $40,963 | $41,407 | 16 | <$5M | AI Deep Dive |
| A & R Scrub-A-Dub, Inc. | Other Services (except Public Administration) | $40,900 | $41,226 | 9 | <$5M | AI Deep Dive |
| Hydro Quick Cleaning Systems, LLC | Administrative and Support and Waste Management | $39,700 | $36,549 | 6 | <$5M | AI Deep Dive |
| Wise Rescue Squad, Inc. | Public Administration | $38,500 | $38,780 | 12 | N/A | AI Deep Dive |
| Safe Haven Enterprises, LLC | Health Care and Social Assistance | $37,200 | $37,468 | 6 | <$5M | AI Deep Dive |
| Wise Energy Group, LLC | Professional, Scientific, and Technical Services | $36,400 | $36,716 | 2 | <$5M | AI Deep Dive |
| B.a. Bartlett Inc. | Construction | $36,000 | $36,247 | 7 | <$5M | AI Deep Dive |
| Wise Glass and Mirror Inc. | Other Services (except Public Administration) | $35,300 | $35,429 | 5 | <$5M | AI Deep Dive |
| Hawkins Electrical Contractors, Inc. | Construction | $33,700 | $33,991 | 4 | <$5M | AI Deep Dive |
| Southwest Surgical Clinic | Health Care and Social Assistance | $33,200 | $33,429 | 5 | <$5M | AI Deep Dive |
| Conway Woodworking, LLC | Construction | $33,100 | $33,481 | 4 | <$5M | AI Deep Dive |
| Conway Woodworking LLC | Construction | $33,100 | $33,411 | 4 | <$5M | AI Deep Dive |
| Wise Glass and Mirror,inc. | Other Services (except Public Administration) | $33,000 | $33,270 | 4 | <$5M | AI Deep Dive |
| Ajd Enterprises LLC | Accommodation and Food Services | $32,600 | $32,873 | 20 | <$5M | AI Deep Dive |
| Anthony E. Collins, P.c. | Professional, Scientific, and Technical Services | $31,400 | $31,610 | 4 | <$5M | AI Deep Dive |