| Hank's Market, Inc. | Retail Trade | $670,400 | $545,257 | 37 | $9.2M | Research |
| Brothers Fire LLC | Agriculture, Forestry, Fishing and Hunting | $129,680 | $130,494 | 49 | <$5M | Research |
| Room One | Other Services (except Public Administration) | $126,577 | $127,496 | 11 | N/A | Research |
| Loyd Logging Inc. | Agriculture, Forestry, Fishing and Hunting | $104,400 | $105,075 | 8 | <$5M | Research |
| Blackcap Builders Collective, LLC | Construction | $103,600 | $104,369 | 10 | <$5M | Research |
| Loup Loup Ski Education Foundation | Arts, Entertainment, and Recreation | $102,601 | $103,282 | 40 | $5.6M | Research |
| John T O'keefe DDS Pllc | Health Care and Social Assistance | $100,821 | $101,266 | 9 | <$5M | Research |
| Sound Consulting Nurse Pllc | Health Care and Social Assistance | $97,875 | $98,492 | 18 | <$5M | Research |
| Norwil Electric Inc. | Construction | $95,150 | $95,628 | 8 | <$5M | Research |
| Ulrich Valley Pharmacy, Inc. | Retail Trade | $93,000 | $93,657 | 9 | <$5M | Research |
| Methow Valley Lumber, Inc. | Retail Trade | $83,700 | $84,451 | 8 | <$5M | Research |
| Methow Valley Sanitation Service, Inc. | Administrative and Support and Waste Management | $78,550 | $79,092 | 6 | <$5M | Research |
| Blue Star Coffee LLC | Manufacturing | $77,200 | $77,681 | 14 | <$5M | Research |
| John T O'keefe, Dds, Pllc | Health Care and Social Assistance | $75,200 | $76,082 | 10 | <$5M | Research |
| Cinnamon Twisp Bakery, INC | Manufacturing | $73,500 | $73,973 | 20 | $7.1M | Research |
| Brandenburg Construction, INC | Construction | $72,735 | $73,509 | 9 | <$5M | Research |
| Brothers Fire LLC | Agriculture, Forestry, Fishing and Hunting | $69,500 | $70,224 | 42 | <$5M | Research |
| Twisp River Suites LLC | Accommodation and Food Services | $64,432 | $64,779 | 10 | <$5M | Research |
| North Cascade Propane Service LLC | Retail Trade | $61,795 | $62,201 | 5 | <$5M | Research |
| Loup Loup Ski Education Foundation | Arts, Entertainment, and Recreation | $57,400 | $57,538 | 41 | $5.7M | Research |
| B & B Excavating Inc. | Construction | $54,795 | $55,145 | 5 | <$5M | Research |
| Sound Consulting Nurse Pllc | Health Care and Social Assistance | $53,210 | $53,582 | 21 | <$5M | Research |
| Twispworks Foundation | Other Services (except Public Administration) | $52,800 | $53,148 | 7 | <$5M | Research |
| Quality Lube and Repair INC | Other Services (except Public Administration) | $52,800 | $53,478 | 4 | <$5M | Research |
| Happy Lark LLC | Administrative and Support and Waste Management | $52,800 | $53,269 | 6 | <$5M | Research |