| Claflin University | Educational Services | $4,777,181 | $4,851,391 | 450 | $54.0M |  Research |
| Family Health Centers Inc. | Health Care and Social Assistance | $2,000,000 | $2,027,233 | 157 | $49.3M | Research |
| Family Health Centers Inc. | Health Care and Social Assistance | $1,995,100 | $2,016,691 | 157 | $49.3M | Research |
| The Methodist Oaks | Health Care and Social Assistance | $1,614,200 | $1,626,576 | 265 | N/A | Research |
| Gulbrandsen Chemicals INC | Manufacturing | $1,170,742 | $1,185,912 | 99 | $98.2M | Research |
| Edisto Regional Health Services | Health Care and Social Assistance | $915,004 | $0 | 56 | N/A | Research |
| Carolina Bridge Co., Inc. | Construction | $793,260 | $801,237 | 71 | $22.0M | Research |
| Quality Models South Carolina INC | Wholesale Trade | $765,000 | $772,336 | 81 | $24.8M | Research |
| Orange Cut Rate Drugs INC | Retail Trade | $722,400 | $727,526 | 66 | $11.5M | Research |
| Mccall-Thomas Engineering Company, Inc. | Professional, Scientific, and Technical Services | $701,027 | $709,089 | 54 | $6.7M | Research |
| Jag-Ob LLC | Unknown | $694,685 | $420,607 | 50 | N/A | Research |
| Michael Delaney Board Chairman | Educational Services | $686,744 | $691,017 | 101 | N/A | Research |
| Tri County Commission On Alcohol & Drug Abuse | Health Care and Social Assistance | $684,400 | $688,001 | 66 | N/A | Research |
| Orangeburg Preparatory Schools, Inc. | Educational Services | $681,360 | $687,511 | 110 | N/A | Research |
| Superior Motors INC | Retail Trade | $521,420 | $527,127 | 49 | $12.3M | Research |
| O'cain Construction Company, Inc. | Construction | $512,038 | $518,519 | 55 | $62.7M | Research |
| Felton Laboratory Charter School | Educational Services | $502,202 | $507,059 | 62 | N/A | Research |
| S&f Investments, Inc. | Accommodation and Food Services | $474,492 | $480,133 | 127 | $22.5M | Research |
| Orangeburg Consolidated School District 5 Hs for Health Prof | Educational Services | $433,200 | $436,882 | 34 | N/A | Research |
| Dt Orangeburg, LLC | Retail Trade | $426,190 | $431,079 | 48 | $12.1M | Research |
| Caw Caw Logging & Trucking LLC | Transportation and Warehousing | $393,000 | $361,432 | 35 | $5.3M | Research |
| Hikari USA Inc. | Manufacturing | $376,724 | $383,254 | 427 | $111.8M | Research |
| Naman Orangeburg II LLC | Accommodation and Food Services | $372,734 | $375,012 | 68 | $21.3M | Research |
| Plaza Automotive of Orangeburg, LLC | Retail Trade | $367,127 | $371,277 | 27 | $6.8M | Research |
| Williams and Williams Attorneys at Law LLC | Professional, Scientific, and Technical Services | $352,845 | $355,822 | 26 | $6.3M | Research |