| Palmetto Nephrology PA | Health Care and Social Assistance | $198,739 | $199,904 | 15 | <$5M |  Research |
| Sunshine Recycling LLC | Retail Trade | $194,200 | $196,605 | 22 | <$5M | Research |
| Central Carolina Endodontics PA | Health Care and Social Assistance | $192,400 | $194,551 | 18 | $5.6M | Research |
| Shady Grove Plantation and Nursery, Inc. | Agriculture, Forestry, Fishing and Hunting | $190,215 | $191,695 | 33 | <$5M | Research |
| Casa Family Systems | Health Care and Social Assistance | $188,900 | $190,183 | 20 | <$5M | Research |
| Gressco Inc. | Administrative and Support and Waste Management | $185,200 | $186,126 | 18 | <$5M | Research |
| Taylor Construction Unlimited LLC | Construction | $183,200 | $185,218 | 19 | $21.6M | Research |
| Palmetto Nephrology, PA | Health Care and Social Assistance | $181,360 | $183,491 | 13 | <$5M | Research |
| Grove Park Pharmacy Hospice Care, LLC | Health Care and Social Assistance | $181,300 | $183,063 | 18 | <$5M | Research |
| South Carolina Surgical, P.a. | Health Care and Social Assistance | $175,600 | $177,751 | 15 | <$5M | Research |
| Orangeburg Eye Center | Health Care and Social Assistance | $173,625 | $175,095 | 17 | $5.3M | Research |
| Estate of Kurt Hamburger | Manufacturing | $166,995 | $168,354 | 31 | $10.9M | Research |
| Inbra Chemical Company INC | Manufacturing | $161,029 | $162,568 | 18 | $17.9M | Research |
| Orangeburg House of Pizza Inc. | Accommodation and Food Services | $160,300 | $161,754 | 42 | $7.5M | Research |
| C.w.h.industries Inc. | Manufacturing | $157,692 | $159,317 | 29 | $10.2M | Research |
| Hibbits Insurance, Inc. | Finance and Insurance | $153,800 | $155,203 | 12 | $6.2M | Research |
| Edisto Home Care and Hospice LLC | Health Care and Social Assistance | $152,298 | $154,113 | 23 | N/A | Research |
| Guardian Angel Tours LLC | Transportation and Warehousing | $145,833 | $0 | 7 | <$5M | Research |
| Tyler's Delivery Express LLC | Transportation and Warehousing | $145,833 | $146,971 | 7 | <$5M | Research |
| Keys to the Kingdom Music Center LLC | Educational Services | $145,833 | $146,676 | 7 | <$5M | Research |
| Mikey's Drive Thru LLC | Accommodation and Food Services | $145,833 | $146,396 | 7 | <$5M | Research |
| Cornerstone Baptist Church | Other Services (except Public Administration) | $140,385 | $141,711 | 31 | N/A | Research |
| Palmetto Infectious Disease Physicians-Sba Small 7a Term | Unknown | $134,000 | $135,262 | 11 | N/A | Research |
| Longwood Plantation-Fhe, LLC | Health Care and Social Assistance | $130,922 | $132,342 | 24 | <$5M | Research |
| Longwood Plantation-Fhe, LLC | Health Care and Social Assistance | $130,921 | $131,549 | 24 | <$5M | Research |