| Orangeburg Coca-Cola Bottling Co. | Retail Trade | $348,545 | $352,321 | 1 | <$5M |  Research |
| Southern Welders Supply Co INC | Wholesale Trade | $315,900 | $319,483 | 26 | $8.0M | Research |
| Low Country Restaurants Inc. | Accommodation and Food Services | $314,800 | $318,123 | 41 | $7.3M | Research |
| Fairey Motor Company | Wholesale Trade | $309,500 | $311,916 | 26 | $8.0M | Research |
| Orangeburg Redi-Mix Concrete, Inc. | Manufacturing | $301,600 | $304,839 | 25 | $24.8M | Research |
| Naman Orangeburg II LLC | Accommodation and Food Services | $270,745 | $273,325 | 68 | $21.3M | Research |
| Williams and Williams Attorneys at Law, LLC | Professional, Scientific, and Technical Services | $262,120 | $264,490 | 23 | $5.6M | Research |
| W & B Enterprises INC | Wholesale Trade | $261,280 | $264,466 | 30 | $7.7M | Research |
| Ontime Transport LLC | Health Care and Social Assistance | $259,847 | $261,471 | 35 | $8.1M | Research |
| Saber of Orangeburg, LLC | Administrative and Support and Waste Management | $259,308 | $262,498 | 74 | $16.0M | Research |
| Pediatric Clinic PA | Health Care and Social Assistance | $259,114 | $262,490 | 18 | $5.6M | Research |
| Orangeburg Milling Company INC | Manufacturing | $252,100 | $253,515 | 31 | $10.9M | Research |
| Pediatric Clinic PA | Health Care and Social Assistance | $249,938 | $252,104 | 24 | $7.5M | Research |
| Phillips Shoes of Hilton Head Inc. | Retail Trade | $247,212 | $249,045 | 24 | <$5M | Research |
| Phillips Shoes of Hilton Head, Inc. | Retail Trade | $247,200 | $250,771 | 31 | <$5M | Research |
| Home Builders Supply Co INC | Retail Trade | $245,700 | $248,487 | 25 | $5.2M | Research |
| W & B Enterprises INC | Wholesale Trade | $242,500 | $245,410 | 32 | $8.2M | Research |
| Lumina Group Inc. | Manufacturing | $241,480 | $243,504 | 27 | $7.5M | Research |
| Ontime Transport LLC | Health Care and Social Assistance | $227,500 | $230,180 | 32 | $7.4M | Research |
| South Carolina Nephrology and Hypertensi | Health Care and Social Assistance | $223,140 | $224,827 | 21 | $6.6M | Research |
| Mid Carolina Timber Co INC | Wholesale Trade | $212,565 | $215,240 | 11 | <$5M | Research |
| Lowcountry Restaurants, INC | Accommodation and Food Services | $210,000 | $213,179 | 57 | $10.1M | Research |
| Mixon Seed Service, INC | Public Administration | $209,710 | $211,853 | 19 | N/A | Research |
| Gibbes Holding Company, Inc. | Retail Trade | $205,865 | $207,746 | 13 | <$5M | Research |
| Dwight's Body Shop Ii, LLC | Other Services (except Public Administration) | $201,368 | $202,515 | 14 | <$5M | Research |