| Tesco & Associates, Inc. | Accommodation and Food Services | $105,295 | $106,404 | 24 | <$5M |  Research |
| Colleton County Commission On Alcohol & Drug | Health Care and Social Assistance | $104,600 | $105,144 | 18 | N/A | Research |
| Fvs, LLC | Agriculture, Forestry, Fishing and Hunting | $104,100 | $105,024 | 13 | <$5M | Research |
| Dukes Barbecue of Walterboro, Inc. | Accommodation and Food Services | $103,912 | $104,922 | 16 | <$5M | Research |
| Colleton County Commission On Alcohol and Drug Abuse | Health Care and Social Assistance | $98,800 | $99,230 | 27 | N/A | Research |
| Interstate Marketers, LLC | Retail Trade | $97,152 | $97,956 | 21 | $5.2M | Research |
| H & H Electrical Services, LLC | Construction | $95,800 | $96,601 | 13 | <$5M | Research |
| Hetrick Harvin & Bonds, LLC | Professional, Scientific, and Technical Services | $89,495 | $90,308 | 8 | <$5M | Research |
| Colleton Tile & Concrete Company Inc. | Construction | $88,440 | $88,818 | 8 | <$5M | Research |
| Walterboro Pole Company, LLC | Agriculture, Forestry, Fishing and Hunting | $88,210 | $88,850 | 12 | <$5M | Research |
| Internal Medicine of Walterboro LLC | Health Care and Social Assistance | $86,467 | $86,974 | 10 | <$5M | Research |
| Tree Trucking LLC | Agriculture, Forestry, Fishing and Hunting | $86,078 | $86,482 | 11 | <$5M | Research |
| Allen Butler Enterprises LLC | Construction | $85,000 | $83,149 | 12 | $13.7M | Research |
| Tree Trucking, Llc. | Agriculture, Forestry, Fishing and Hunting | $83,938 | $84,611 | 6 | <$5M | Research |
| Jai Ambe LLC | Accommodation and Food Services | $83,640 | $84,238 | 15 | <$5M | Research |
| Lucas Electric Company, INC | Construction | $82,580 | $83,186 | 9 | <$5M | Research |
| Lowcountry Aviation Company Asset Rentals, LLC | Real Estate and Rental and Leasing | $81,245 | $82,229 | 13 | $5.9M | Research |
| Lowcountry Collision, LLC | Other Services (except Public Administration) | $80,850 | $81,580 | 7 | <$5M | Research |
| Chelsea Hospitality LLC | Accommodation and Food Services | $80,114 | $80,584 | 19 | $5.9M | Research |
| Iiu INC | Retail Trade | $79,830 | $80,480 | 7 | <$5M | Research |
| Wildwood Contractors, Inc. | Administrative and Support and Waste Management | $77,727 | $68,259 | 11 | <$5M | Research |
| Wildwood Contractors Inc. | Construction | $77,500 | $77,933 | 9 | <$5M | Research |
| Brice W. Herndon & Sons Funeral Home | Other Services (except Public Administration) | $77,000 | $77,633 | 12 | <$5M | Research |
| Camie H. Hiers | Accommodation and Food Services | $76,984 | $77,492 | 17 | <$5M | Research |
| Compass South, Inc. | Agriculture, Forestry, Fishing and Hunting | $76,700 | $77,305 | 5 | <$5M | Research |