| John Soules Foods, INC | Wholesale Trade | $10,000,000 | $10,222,466 | 500 | $128.7M |  Research |
| Techserv Consulting and Traning, Ltd | Professional, Scientific, and Technical Services | $6,900,700 | $6,998,652 | 364 | $51.0M | Research |
| Caregivers Home Health Texas INC | Health Care and Social Assistance | $3,736,585 | $3,786,133 | 500 | $85.6M | Research |
| Rex Hide Incorporated | Management of Companies and Enterprises | $3,693,500 | $3,736,693 | 264 | $43.4M | Research |
| Bienville Holdings, Ltd | Health Care and Social Assistance | $3,051,300 | $3,090,458 | 183 | $31.3M | Research |
| Andrews Center | Health Care and Social Assistance | $2,835,022 | $2,866,916 | 298 | N/A | Research |
| Pine Cove INC | Other Services (except Public Administration) | $2,548,800 | $2,577,403 | 250 | $47.8M | Research |
| Helping Hands Homecare, Ltd. | Health Care and Social Assistance | $2,516,900 | $2,549,200 | 484 | $82.9M | Research |
| Hospice of East Texas | Health Care and Social Assistance | $2,508,180 | $2,538,975 | 220 | N/A | Research |
| Grace Community of Tyler | Other Services (except Public Administration) | $2,321,500 | $2,349,040 | 401 | $76.6M | Research |
| Kp Engineering LP | Professional, Scientific, and Technical Services | $2,302,013 | $2,328,376 | 61 | $7.5M | Research |
| Kp Engineering LP | Professional, Scientific, and Technical Services | $2,000,000 | $2,011,178 | 60 | $7.4M | Research |
| Rex-Hide Incorporated | Management of Companies and Enterprises | $2,000,000 | $2,021,778 | 242 | $39.8M | Research |
| Classic Tyler Motors, Inc. | Retail Trade | $1,971,010 | $1,994,169 | 183 | $46.1M | Research |
| Vme Fabricators, Inc. | Manufacturing | $1,918,000 | $1,940,086 | 136 | $33.2M | Research |
| Azalea Orthopedics and Sports Medicine Clinic, PA | Health Care and Social Assistance | $1,904,333 | $1,922,750 | 232 | $72.8M | Research |
| Gg Distributing, LLC | Wholesale Trade | $1,902,220 | $1,919,868 | 182 | $46.8M | Research |
| Estes, Mcclure & Associates, Inc. DBA Ema Engineering and Co | Professional, Scientific, and Technical Services | $1,875,000 | $1,890,159 | 101 | $12.5M | Research |
| Cumberland Academy | Educational Services | $1,846,700 | $1,858,387 | 249 | N/A | Research |
| Northeast Texas Home Health Agency, Ltd | Health Care and Social Assistance | $1,836,300 | $1,860,223 | 199 | $34.1M | Research |
| Estes Mcclure & Associates Inc. | Professional, Scientific, and Technical Services | $1,831,970 | $1,838,585 | 154 | $19.0M | Research |
| Charles R. Gordon, M.d., P.a. | Health Care and Social Assistance | $1,823,000 | $309,767 | 152 | $47.7M | Research |
| Henry & Peters PC | Professional, Scientific, and Technical Services | $1,720,378 | $1,731,656 | 105 | $33.4M | Research |
| Tyler Motor Company, INC | Retail Trade | $1,680,697 | $1,692,182 | 115 | $29.0M | Research |
| Charles L. Heaton, M.d., P.a. | Health Care and Social Assistance | $1,680,258 | $1,689,947 | 121 | $38.0M | Research |