| Cmd Inc. | Accommodation and Food Services | $336,300 | $340,037 | 41 | $5.0M | AI Deep Dive |
| Bolling Steel Co. Inc. | Manufacturing | $335,512 | $337,003 | 29 | $7.1M | AI Deep Dive |
| Lakeside Baptist Church | Other Services (except Public Administration) | $327,000 | $330,361 | 84 | N/A | AI Deep Dive |
| Bolling Steel Company, Inc. | Manufacturing | $326,600 | $329,639 | 31 | $7.6M | AI Deep Dive |
| Damon Company of Salem, Inc. | Manufacturing | $325,600 | $327,300 | 28 | $7.8M | AI Deep Dive |
| Pinkerton Chevrolet, Inc. | Retail Trade | $323,325 | $325,504 | 32 | $8.1M | AI Deep Dive |
| Aaron J. Conner General Contractor Inc. | Construction | $321,697 | $323,708 | 28 | $8.7M | AI Deep Dive |
| Aaron J. Conner General Contractor, INC | Construction | $316,101 | $317,998 | 27 | $8.4M | AI Deep Dive |
| Mechanical Development Company Incorporated | Manufacturing | $313,800 | $315,883 | 37 | $9.0M | AI Deep Dive |
| Skyline Door & Hardware, INC | Retail Trade | $312,000 | $315,590 | 24 | <$5M | AI Deep Dive |
| Southwest Tool Supply | Manufacturing | $300,300 | $301,877 | 21 | $5.5M | AI Deep Dive |
| Linx of Roanoke LLC | Arts, Entertainment, and Recreation | $298,395 | $300,666 | 42 | $5.9M | AI Deep Dive |
| Famous Anthony's of Salem Inc. | Accommodation and Food Services | $290,715 | $292,750 | 46 | $8.2M | AI Deep Dive |
| Trinity Foods, LLC | Accommodation and Food Services | $290,125 | $292,801 | 89 | $15.8M | AI Deep Dive |
| Fellowship Community Church INC | Other Services (except Public Administration) | $286,200 | $0 | 32 | N/A | AI Deep Dive |
| Linx of Roanoke, LLC | Arts, Entertainment, and Recreation | $285,900 | $288,068 | 18 | <$5M | AI Deep Dive |
| Anchor Sales and Service Inc. | Retail Trade | $284,270 | $286,876 | 22 | $5.3M | AI Deep Dive |
| Key Living Options, Inc. | Health Care and Social Assistance | $282,300 | $284,919 | 46 | $7.8M | AI Deep Dive |
| Tbc Associates II L.c. | Administrative and Support and Waste Management | $276,700 | $280,104 | 40 | $7.6M | AI Deep Dive |
| Salem Montessori School INC | Health Care and Social Assistance | $275,300 | $278,068 | 52 | $8.4M | AI Deep Dive |
| American Door & Glass - Southwest Virginia, Inc. | Construction | $274,775 | $276,988 | 43 | $14.7M | AI Deep Dive |
| Kinnan Enterprises INC | Real Estate and Rental and Leasing | $273,585 | $274,280 | 37 | $16.7M | AI Deep Dive |
| Kinnan Enterprises INC | Real Estate and Rental and Leasing | $273,583 | $275,308 | 35 | $15.8M | AI Deep Dive |
| Eagle 21 Inc. | Accommodation and Food Services | $271,565 | $274,578 | 33 | $5.9M | AI Deep Dive |
| Dental Associates Pllc | Health Care and Social Assistance | $268,972 | $270,787 | 24 | $5.6M | AI Deep Dive |