| Katch Construction Supply Company | Construction | $260,045 | $262,489 | 45 | $51.3M | AI Deep Dive |
| Mac and Bob's | Accommodation and Food Services | $259,000 | $262,266 | 102 | $18.1M | AI Deep Dive |
| Brown and Son LLC | Transportation and Warehousing | $257,476 | $259,218 | 18 | <$5M | AI Deep Dive |
| Brown and Son LLC | Transportation and Warehousing | $251,600 | $253,895 | 18 | <$5M | AI Deep Dive |
| Cmd INC | Accommodation and Food Services | $240,200 | $242,509 | 55 | $9.8M | AI Deep Dive |
| Jayam Inc. | Accommodation and Food Services | $240,200 | $242,411 | 55 | $17.2M | AI Deep Dive |
| Virginia Varsity Transfer INC | Transportation and Warehousing | $240,100 | $241,667 | 27 | $7.2M | AI Deep Dive |
| Katch Construction Supply Company | Construction | $237,918 | $239,149 | 38 | $43.3M | AI Deep Dive |
| Ditch Witch of Roanoke, Inc. | Wholesale Trade | $236,740 | $238,238 | 17 | $5.2M | AI Deep Dive |
| Innovative Community Solutions, Inc. | Health Care and Social Assistance | $232,745 | $235,840 | 40 | $6.8M | AI Deep Dive |
| Abc's of Applied Behavior Analysis Inc. | Health Care and Social Assistance | $230,537 | $231,465 | 24 | <$5M | AI Deep Dive |
| Dental Associates Pllc | Health Care and Social Assistance | $229,565 | $231,230 | 23 | $5.3M | AI Deep Dive |
| Virginia Eastern Company LLC | Accommodation and Food Services | $226,870 | $227,929 | 21 | $6.6M | AI Deep Dive |
| Salem Professional Baseball Club INC | Arts, Entertainment, and Recreation | $219,500 | $221,847 | 22 | <$5M | AI Deep Dive |
| Poarch Law Firm PC | Professional, Scientific, and Technical Services | $215,641 | $216,875 | 21 | $5.1M | AI Deep Dive |
| Noy Noy LLC | Accommodation and Food Services | $211,869 | $213,488 | 45 | $8.0M | AI Deep Dive |
| Salem Montessori School INC | Educational Services | $208,520 | $210,304 | 38 | <$5M | AI Deep Dive |
| Famous Anthony's of Salem INC | Accommodation and Food Services | $207,180 | $210,201 | 42 | $7.5M | AI Deep Dive |
| Abc's of Applied Behavior Analysis, Inc. | Health Care and Social Assistance | $205,610 | $189,899 | 23 | <$5M | AI Deep Dive |
| Prillaman Mechanical. Heating and A/c. Inc. | Other Services (except Public Administration) | $203,750 | $205,142 | 18 | <$5M | AI Deep Dive |
| S & W Tom's Distributors, Inc. | Retail Trade | $203,100 | $204,240 | 22 | $5.4M | AI Deep Dive |
| S&w Toms Distributors INC | Retail Trade | $202,618 | $203,918 | 22 | $5.4M | AI Deep Dive |
| T. C. Squared, Inc. | Other Services (except Public Administration) | $200,700 | $202,718 | 37 | $7.3M | AI Deep Dive |
| Eagle 21, Inc. | Accommodation and Food Services | $193,975 | $196,303 | 33 | $5.9M | AI Deep Dive |
| El Rodeo Salem INC | Accommodation and Food Services | $190,000 | $192,069 | 20 | <$5M | AI Deep Dive |